Diethylpropion Hydrochloride	(dye-ETH-il-PROE-pee-on HYE-droe-KLOR-ide)
Trade Name(s):	Diethylpropion Hydrochloride   ·Tablets 25 mg   ·Tablets, sustained-release 75 mg Indicates Canadian Trade Name.
Class:	Anorexiant
Action:	Stimulates satiety center in brain, causing appetite suppression. Absorption: Rapidly absorbed.
	Distribution: Crosses the blood-brain barrier and the placenta.
	Metabolism: Extensively metabolized, involving N-dealkylation and reduction, to many active metabolites.
	Excretion: 75% to 100% excreted in the urine. Plasma t ½ of aminoketone metabolites is 4 to 6 h.
Indications:	Short-term (few weeks) adjunct to diet plan to reduce weight.
Contraindications:	Advanced arteriosclerosis; symptomatic cardiovascular disease; moderate to severe hypertension; hyperthyroidism; hypersensitivity to sympathomimetic amines; glaucoma; agitated states; history of drug abuse; concurrent use with or within 14 days of MAOI; coadministration with other CNS stimulants.
Interactions:
	Guanethidine May decrease hypotensive effect.
	MAOIs, furazolidone Hypertensive crisis and intracranial hemorrhage may occur.
	SSRIs Sympathomimetic effects of diethylpropion may be increased; increased risk of serotonin syndrome.
	Tricyclic antidepressants May decrease anorexiant effect.
Lab Test Interferences:	None well documented.
Adverse Reactions:
	cardiovascular: Palpitations; tachycardia; arrhythmias; hypertension; hypotension.
	cns: Overstimulation; dizziness; insomnia; euphoria; tremor; headache.
	dermatologic: Excessive sweating; flushing.
	eent: Mydriasis; blurred vision.
	gi: Dry mouth; unpleasant taste; nausea; diarrhea; constipation; stomach pain.
	gu: Dysuria; urinary frequency; impotence; menstrual disturbances.
	hematologic: Bone marrow depression; agranulocytosis; leukopenia.
	miscellaneous: Hair loss; myalgia; gynecomastia; allergic reactions (eg, urticaria; rash; erythema).
Precautions:
	Monitoring: Withhold medication if there is a BP increase of 20 mm Hg or if heart dysrhythmia or increase in heart rate develop.
	Pregnancy: Category B .
	Lactation: Excreted in breast milk.
	Children: Not recommended in children younger than 16 yr of age.
	CV effects Diethylpropion may cause or aggravate hypertension or arrhythmias.
	Convulsions Diethylpropion may aggravate convulsions; dose titration or discontinuance may be necessary.
	Drug dependence Related to amphetamine; has abuse potential.
	Tolerance Tolerance may occur.
Overdosage:	Signs & symptoms Restlessness, tremor, hyperreflexia, fever, tachypnea, dizziness, panic, aggression, hallucinations, seizure, coma, arrhythmias, hypotension, hypertension, death.
Patient/Family Education:	Explain potential for increased agitation, palpitations, and dizziness, and identify precaution to take when performing tasks that require physical coordination or mental concentration. Tell patient to record weight weekly. Explain that drug will make patient feel less hungry and thus make it easier to adhere to diet but that weight loss will occur only with calorie reduction and increased physical activity. Instruct patient on missed medication procedure: if less than 2 h, take medication; if more than 2 h, wait until next scheduled dose. Do not double up on medication. Advise patient to limit intake of coffee, tea, cocoa, chocolate, and caffeinated soft drinks. Identify techniques to prevent or treat dry mouth.